AMBRISENTAN vs OPSUMIT

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. AMBRISENTAN and OPSUMIT are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AMBRISENTAN	OPSUMIT
Rating	66/100	New
Pharmacy pays	~$255.61 /30	—
Type	RX	RX
Active ingredient	AMBRISENTAN	MACITENTAN
Manufacturer	Zydus Pharms USA Inc	Actelion
Dosage forms	Tablet	Tablet
Drug class	Endothelin Receptor Antagonist	Endothelin Receptor Antagonist
Boxed warning	Boxed warning	Boxed warning
Half-life	—	about 16 hours (apparent elimination half-life)
Treats	Pulmonary Hypertension	Pulmonary Hypertension

ambrisentan opsumit

Rating

66/100

New

Pharmacy pays

~$255.61 /30

—

Type

Active ingredient

AMBRISENTAN

MACITENTAN

Manufacturer

Zydus Pharms USA Inc

Actelion

Dosage forms

Tablet

Drug class

Endothelin Receptor Antagonist

Boxed warning

Half-life

—

about 16 hours (apparent elimination half-life)

Treats

Pulmonary Hypertension

Frequently asked questions

What is the difference between Ambrisentan and Opsumit?

Ambrisentan contains Ambrisentan, while Opsumit contains Macitentan — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.