AMBIEN vs SECONAL SODIUM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. AMBIEN and SECONAL SODIUM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AMBIEN	SECONAL SODIUM
Rating	70/100	New
Pharmacy pays	~$1.04 /30	—
Type	RX	RX
Active ingredient	ZOLPIDEM TARTRATE	SECOBARBITAL SODIUM
Manufacturer	Cosette	Lilly
Dosage forms	Tablet	Suppository, Capsule
Drug class	Gamma-Aminobutyric Acid A Receptor Positive Modulator	—
Boxed warning	Boxed warning	None
Half-life	about 2.5 hours (mean 2.5-2.6 hours; range roughly 1.4 to 4.5 hours) in healthy adults	—
Treats	Sleep Initiation and Maintenance Disorders	Sleep Initiation and Maintenance Disorders

ambien seconal sodium

Rating

70/100

New

Pharmacy pays

~$1.04 /30

—

Type

Active ingredient

ZOLPIDEM TARTRATE

SECOBARBITAL SODIUM

Manufacturer

Cosette

Lilly

Dosage forms

Tablet

Suppository, Capsule

Drug class

Gamma-Aminobutyric Acid A Receptor Positive Modulator

—

Boxed warning

None

Half-life

about 2.5 hours (mean 2.5-2.6 hours; range roughly 1.4 to 4.5 hours) in healthy adults

—

Treats

Sleep Initiation and Maintenance Disorders

Frequently asked questions

What is the difference between Ambien and Seconal Sodium?

Ambien contains Zolpidem Tartrate, while Seconal Sodium contains Secobarbital Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.