ALPHAGAN P vs NOVAFED

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. ALPHAGAN P and NOVAFED are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ALPHAGAN P	NOVAFED
Rating	72/100	70/100
Pharmacy pays	$10.38 /mL	~$8.29 /30
Type	RX	RX
Active ingredient	BRIMONIDINE TARTRATE	PSEUDOEPHEDRINE HYDROCHLORIDE
Manufacturer	Abbvie	Sanofi Aventis US
Dosage forms	Drops	Capsule, extended release
Drug class	Alpha-Adrenergic Agonist	Alpha-Adrenergic Agonist
Boxed warning	None	None
Half-life	—	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)
Treats	Open-Angle Glaucoma	Asthma, Common Cold, Perennial Allergic Rhinitis

alphagan p novafed

Rating

72/100

70/100

Pharmacy pays

$10.38 /mL

~$8.29 /30

Type

Active ingredient

BRIMONIDINE TARTRATE

PSEUDOEPHEDRINE HYDROCHLORIDE

Manufacturer

Abbvie

Sanofi Aventis US

Dosage forms

Drops

Capsule, extended release

Drug class

Alpha-Adrenergic Agonist

Boxed warning

None

Half-life

—

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

Treats

Open-Angle Glaucoma

Asthma, Common Cold, Perennial Allergic Rhinitis

Get novafed

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Frequently asked questions

Which is better-rated, Alphagan P or Novafed?

By our independent rating, Alphagan P scores higher — 3.6 vs 3.5 out of 5 for Novafed. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Alphagan P and Novafed?

Alphagan P contains Brimonidine Tartrate, while Novafed contains Pseudoephedrine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.