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ALLI vs PLEGINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Rating

72/100
New

Pharmacy pays

~$207.04 /30
~$3.86 /30

Type

OTC
RX

Active ingredient

ORLISTAT
PHENDIMETRAZINE TARTRATE

Dosage forms

Capsule
Tablet

Drug class

Sympathomimetic Amine Anorectic

Boxed warning

None
None

Treats

Obesity
Obesity

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Where to buy

Buy over-the-counter from trusted retailers.

Frequently asked questions

Which is cheaper, Alli or Plegine?

Plegine costs pharmacies less to acquire — about $3.86 vs $207.04 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Alli and Plegine?

Alli contains Orlistat, while Plegine contains Phendimetrazine Tartrate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.