ALEVE-D SINUS & COLD vs NAPROXEN SODIUM AND PSEUDOEPHEDRINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Attribute	ALEVE-D SINUS & COLD	NAPROXEN SODIUM AND PSEUDOEPHEDRINE HYDROCHLORIDE
Rating	New	64/100
Pharmacy pays	$0.06 /mL	$0.06 /mL
Type	RX	OTC
Active ingredient	NAPROXEN SODIUM AND PSEUDOEPHEDRINE HYDROCHLORIDE	NAPROXEN SODIUM AND PSEUDOEPHEDRINE HYDROCHLORIDE
Manufacturer	Bayer Pharms	Perrigo
Dosage forms	Tablet, extended release	Tablet, Tablet, extended release, Multilayer, extended release
Drug class	—	—
Boxed warning	None	None
Half-life	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

aleve-d sinus & cold naproxen sodium and pseudoephedrine hydrochloride

Rating

New

64/100

Pharmacy pays

$0.06 /mL

Type

OTC

Active ingredient

NAPROXEN SODIUM AND PSEUDOEPHEDRINE HYDROCHLORIDE

Manufacturer

Bayer Pharms

Perrigo

Dosage forms

Tablet, extended release

Tablet, Tablet, extended release, Multilayer, extended release

Drug class

—

Boxed warning

None

Half-life

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

Get naproxen sodium and pseudoephedrine hydrochloridehigher-rated option

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Frequently asked questions

Which is cheaper, Aleve-D Sinus & Cold or Naproxen Sodium and Pseudoephedrine Hydrochloride?

Pharmacies pay about the same to acquire either one — roughly $0.06 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Aleve-D Sinus & Cold and Naproxen Sodium and Pseudoephedrine Hydrochloride?

Both Aleve-D Sinus & Cold and Naproxen Sodium and Pseudoephedrine Hydrochloride share the active ingredient Naproxen Sodium and Pseudoephedrine Hydrochloride, but Aleve-D Sinus & Cold is sold as RX and Naproxen Sodium and Pseudoephedrine Hydrochloride as OTC.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.