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ALDOMET vs ZANAFLEX

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. ALDOMET and ZANAFLEX are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

70/100
New

Pharmacy pays

~$225.00 /30
~$1.00 /30

Type

RX
RX

Active ingredient

METHYLDOPA
TIZANIDINE HYDROCHLORIDE

Manufacturer

Dosage forms

Tablet
Capsule, Tablet

Drug class

Central Alpha-2 Adrenergic Agonist
Central Alpha-2 Adrenergic Agonist

Boxed warning

None
None

Half-life

about 105 minutes (roughly 1.75 hours)
about 2.5 hours

Treats

Hypertension
Muscle Cramp, Muscle Rigidity, Muscle Spasticity

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Frequently asked questions

Which is cheaper, Aldomet or Zanaflex?

Zanaflex costs pharmacies less to acquire — about $1.00 vs $225.00 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Aldomet and Zanaflex?

Aldomet contains Methyldopa, while Zanaflex contains Tizanidine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.