ALDOMET vs GUANFACINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Possible drug interaction. ALDOMET and GUANFACINE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ALDOMET	GUANFACINE HYDROCHLORIDE
Rating	70/100	72/100
Pharmacy pays	~$225.00 /30	~$5.26 /30
Type	RX	RX
Active ingredient	METHYLDOPA	GUANFACINE HYDROCHLORIDE
Manufacturer	Merck	Actavis Elizabeth
Dosage forms	Tablet	Tablet
Drug class	Central Alpha-2 Adrenergic Agonist	Central Alpha-2 Adrenergic Agonist
Boxed warning	None	None
Half-life	about 105 minutes (roughly 1.75 hours)	—
Treats	Hypertension	Attention Deficit Disorder with Hyperactivity, Hypertension

aldomet guanfacine hydrochloride

Rating

70/100

72/100

Pharmacy pays

~$225.00 /30

~$5.26 /30

Type

Active ingredient

METHYLDOPA

GUANFACINE HYDROCHLORIDE

Manufacturer

Merck

Actavis Elizabeth

Dosage forms

Tablet

Drug class

Central Alpha-2 Adrenergic Agonist

Boxed warning

None

Half-life

about 105 minutes (roughly 1.75 hours)

—

Treats

Hypertension

Attention Deficit Disorder with Hyperactivity, Hypertension

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Frequently asked questions

Which is better-rated, Aldomet or Guanfacine Hydrochloride?

By our independent rating, Guanfacine Hydrochloride scores higher — 3.6 vs 3.5 out of 5 for Aldomet. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Aldomet or Guanfacine Hydrochloride?

Guanfacine Hydrochloride costs pharmacies less to acquire — about $5.26 vs $225.00 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Aldomet and Guanfacine Hydrochloride?

Aldomet contains Methyldopa, while Guanfacine Hydrochloride contains Guanfacine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.