AFRINOL vs ALPHAGAN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 12, 2026·How we rate

Possible drug interaction. AFRINOL and ALPHAGAN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AFRINOL	ALPHAGAN
Rating	New	72/100
Pharmacy pays	~$8.29 /30	$10.41 /mL
Type	RX	RX
Active ingredient	PSEUDOEPHEDRINE SULFATE	BRIMONIDINE TARTRATE
Manufacturer	Schering Plough	Allergan
Dosage forms	Tablet, extended release	Drops
Drug class	Alpha-Adrenergic Agonist	Alpha-Adrenergic Agonist
Boxed warning	None	None
Half-life	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)	—
Treats	Asthma, Common Cold, Perennial Allergic Rhinitis	Open-Angle Glaucoma

afrinol alphagan

Rating

New

72/100

Pharmacy pays

~$8.29 /30

$10.41 /mL

Type

Active ingredient

PSEUDOEPHEDRINE SULFATE

BRIMONIDINE TARTRATE

Manufacturer

Schering Plough

Allergan

Dosage forms

Tablet, extended release

Drops

Drug class

Alpha-Adrenergic Agonist

Boxed warning

None

Half-life

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

—

Treats

Asthma, Common Cold, Perennial Allergic Rhinitis

Open-Angle Glaucoma

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Frequently asked questions

What is the difference between Afrinol and Alphagan?

Afrinol contains Pseudoephedrine Sulfate, while Alphagan contains Brimonidine Tartrate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.