AFINITOR vs FYARRO

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. AFINITOR and FYARRO are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AFINITOR	FYARRO
Rating	70/100	New
Pharmacy pays	~$229.16 /30	~$48.61 /30
Type	RX	RX
Active ingredient	EVEROLIMUS	SIROLIMUS
Manufacturer	Novartis	Aadi
Dosage forms	Tablet	Injectable
Drug class	Kinase Inhibitor	Kinase Inhibitor
Boxed warning	None	None
Half-life	about 30 hours (mean terminal elimination half-life)	—
Treats	—	Lymphangioleiomyomatosis, Perivascular Epithelioid Cell Neoplasms

afinitor fyarro

Rating

70/100

New

Pharmacy pays

~$229.16 /30

~$48.61 /30

Type

Active ingredient

EVEROLIMUS

SIROLIMUS

Manufacturer

Novartis

Aadi

Dosage forms

Tablet

Injectable

Drug class

Kinase Inhibitor

Boxed warning

None

Half-life

about 30 hours (mean terminal elimination half-life)

—

Treats

—

Lymphangioleiomyomatosis, Perivascular Epithelioid Cell Neoplasms

Frequently asked questions

Which is cheaper, Afinitor or Fyarro?

Fyarro costs pharmacies less to acquire — about $48.61 vs $229.16 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Afinitor and Fyarro?

Afinitor contains Everolimus, while Fyarro contains Sirolimus — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.