AFINITOR vs COTELLIC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. AFINITOR and COTELLIC are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	AFINITOR	COTELLIC
Rating	70/100	70/100
Pharmacy pays	~$229.16 /30	—
Type	RX	RX
Active ingredient	EVEROLIMUS	COBIMETINIB FUMARATE
Manufacturer	Novartis	Genentech Inc
Dosage forms	Tablet	Tablet
Drug class	Kinase Inhibitor	Kinase Inhibitor
Boxed warning	None	None
Half-life	about 30 hours (mean terminal elimination half-life)	—
Treats	—	Melanoma

afinitor cotellic

Rating

70/100

Pharmacy pays

~$229.16 /30

—

Type

Active ingredient

EVEROLIMUS

COBIMETINIB FUMARATE

Manufacturer

Novartis

Genentech Inc

Dosage forms

Tablet

Drug class

Kinase Inhibitor

Boxed warning

None

Half-life

about 30 hours (mean terminal elimination half-life)

—

Treats

—

Melanoma

Frequently asked questions

Which is better-rated, Afinitor or Cotellic?

Afinitor and Cotellic are tied at 3.5 out of 5 by our independent rating.

What is the difference between Afinitor and Cotellic?

Afinitor contains Everolimus, while Cotellic contains Cobimetinib Fumarate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.