ADZENYS ER vs APTENSIO XR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. ADZENYS ER and APTENSIO XR are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ADZENYS ER	APTENSIO XR
Rating	New	New
Pharmacy pays	~$478.55 /30	~$18.94 /30
Type	RX	RX
Active ingredient	AMPHETAMINE	METHYLPHENIDATE HYDROCHLORIDE
Manufacturer	Neos Theraps Inc	Rhodes Pharms
Dosage forms	Suspension, extended release	Capsule, extended release
Drug class	Central Nervous System Stimulant	Central Nervous System Stimulant
Boxed warning	None	Boxed warning
Half-life	about 10 to 11 hours for d-amphetamine (range 9.8 to 11 hours) and about 12 to 14 hours for l-amphetamine (range 11.5 to 13.8 hours) in healthy adults	about 2.7 hours
Treats	Attention Deficit Disorder with Hyperactivity, Narcolepsy	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

adzenys er aptensio xr

Rating

New

Pharmacy pays

~$478.55 /30

~$18.94 /30

Type

Active ingredient

AMPHETAMINE

METHYLPHENIDATE HYDROCHLORIDE

Manufacturer

Neos Theraps Inc

Rhodes Pharms

Dosage forms

Suspension, extended release

Capsule, extended release

Drug class

Central Nervous System Stimulant

Boxed warning

None

Boxed warning

Half-life

about 10 to 11 hours for d-amphetamine (range 9.8 to 11 hours) and about 12 to 14 hours for l-amphetamine (range 11.5 to 13.8 hours) in healthy adults

about 2.7 hours

Treats

Attention Deficit Disorder with Hyperactivity, Narcolepsy

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

Frequently asked questions

Which is cheaper, Adzenys ER or Aptensio XR?

Aptensio XR costs pharmacies less to acquire — about $18.94 vs $478.55 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Adzenys ER and Aptensio XR?

Adzenys ER contains Amphetamine, while Aptensio XR contains Methylphenidate Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.