ADVIL vs NAPROXEN SODIUM AND PSEUDOEPHEDRINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Attribute	ADVIL	NAPROXEN SODIUM AND PSEUDOEPHEDRINE HYDROCHLORIDE
Rating	72/100	64/100
Pharmacy pays	$0.04 /mL	$0.06 /mL
Type	OTC	OTC
Active ingredient	IBUPROFEN	NAPROXEN SODIUM AND PSEUDOEPHEDRINE HYDROCHLORIDE
Manufacturer	Haleon US Holdings	Perrigo
Dosage forms	Tablet, Capsule	Tablet, Tablet, extended release, Multilayer, extended release
Drug class	Nonsteroidal Anti-Inflammatory Drug	—
Boxed warning	None	None
Half-life	about 1.8 to 2.0 hours	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)
Treats	Juvenile Arthritis, Rheumatoid Arthritis, Bursitis	—

advil naproxen sodium and pseudoephedrine hydrochloride

Rating

72/100

64/100

Pharmacy pays

$0.04 /mL

$0.06 /mL

Type

OTC

Active ingredient

IBUPROFEN

NAPROXEN SODIUM AND PSEUDOEPHEDRINE HYDROCHLORIDE

Manufacturer

Haleon US Holdings

Perrigo

Dosage forms

Tablet, Capsule

Tablet, Tablet, extended release, Multilayer, extended release

Drug class

Nonsteroidal Anti-Inflammatory Drug

—

Boxed warning

None

Half-life

about 1.8 to 2.0 hours

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

Treats

Juvenile Arthritis, Rheumatoid Arthritis, Bursitis

—

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Frequently asked questions

Which is better-rated, Advil or Naproxen Sodium and Pseudoephedrine Hydrochloride?

By our independent rating, Advil scores higher — 3.6 vs 3.2 out of 5 for Naproxen Sodium and Pseudoephedrine Hydrochloride. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Advil or Naproxen Sodium and Pseudoephedrine Hydrochloride?

Advil costs pharmacies less to acquire — about $0.04 vs $0.06 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Advil and Naproxen Sodium and Pseudoephedrine Hydrochloride?

Advil contains Ibuprofen, while Naproxen Sodium and Pseudoephedrine Hydrochloride contains Naproxen Sodium and Pseudoephedrine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.