ADVIL vs MUCINEX D

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Attribute	ADVIL	MUCINEX D
Rating	72/100	New
Pharmacy pays	$0.04 /mL	$0.07 /mL
Type	OTC	OTC
Active ingredient	IBUPROFEN	GUAIFENESIN AND PSEUDOEPHEDRINE HYDROCHLORIDE
Manufacturer	Haleon US Holdings	Rb Hlth
Dosage forms	Tablet, Capsule	Tablet, extended release
Drug class	Nonsteroidal Anti-Inflammatory Drug	—
Boxed warning	None	None
Half-life	about 1.8 to 2.0 hours	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)
Treats	Juvenile Arthritis, Rheumatoid Arthritis, Bursitis	—

advil mucinex d

Rating

72/100

New

Pharmacy pays

$0.04 /mL

$0.07 /mL

Type

OTC

Active ingredient

IBUPROFEN

GUAIFENESIN AND PSEUDOEPHEDRINE HYDROCHLORIDE

Manufacturer

Haleon US Holdings

Rb Hlth

Dosage forms

Tablet, Capsule

Tablet, extended release

Drug class

Nonsteroidal Anti-Inflammatory Drug

—

Boxed warning

None

Half-life

about 1.8 to 2.0 hours

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

Treats

Juvenile Arthritis, Rheumatoid Arthritis, Bursitis

—

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Where to buy

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Frequently asked questions

Which is cheaper, Advil or Mucinex D?

Advil costs pharmacies less to acquire — about $0.04 vs $0.07 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Advil and Mucinex D?

Advil contains Ibuprofen, while Mucinex D contains Guaifenesin and Pseudoephedrine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.