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ADVIL vs IBUPROFEN AND DIPHENHYDRAMINE CITRATE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Rating

72/100
New

Pharmacy pays

$0.04 /mL
$0.04 /mL

Type

OTC
OTC

Active ingredient

IBUPROFEN
DIPHENHYDRAMINE CITRATE AND IBUPROFEN

Dosage forms

Tablet, Capsule
Tablet

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None
None

Half-life

about 1.8 to 2.0 hours
about 1.8 to 2.0 hours

Treats

Juvenile Arthritis, Rheumatoid Arthritis, Bursitis

Get advilhigher-rated option

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Where to buy

Buy over-the-counter from trusted retailers.

Frequently asked questions

Which is cheaper, Advil or Ibuprofen and Diphenhydramine Citrate?

Ibuprofen and Diphenhydramine Citrate costs pharmacies less to acquire — about $0.04 vs $0.04 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Advil and Ibuprofen and Diphenhydramine Citrate?

Advil contains Ibuprofen, while Ibuprofen and Diphenhydramine Citrate contains Diphenhydramine Citrate and Ibuprofen — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.