ADVIL MIGRAINE LIQUI-GELS vs PENNSAID

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Attribute	ADVIL MIGRAINE LIQUI-GELS	PENNSAID
Rating	70/100	New
Pharmacy pays	$0.04 /mL	$0.36 /mL
Type	OTC	RX
Active ingredient	IBUPROFEN	DICLOFENAC SODIUM
Manufacturer	Haleon US Holdings	Horizon
Dosage forms	Capsule	Solution
Drug class	Nonsteroidal Anti-Inflammatory Drug	Nonsteroidal Anti-Inflammatory Drug
Boxed warning	None	None
Half-life	about 1.8 to 2.0 hours	about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)
Treats	Juvenile Arthritis, Rheumatoid Arthritis, Bursitis	Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

advil migraine liqui-gels pennsaid

Rating

70/100

New

Pharmacy pays

$0.04 /mL

$0.36 /mL

Type

OTC

Active ingredient

IBUPROFEN

DICLOFENAC SODIUM

Manufacturer

Haleon US Holdings

Horizon

Dosage forms

Capsule

Solution

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None

Half-life

about 1.8 to 2.0 hours

about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)

Treats

Juvenile Arthritis, Rheumatoid Arthritis, Bursitis

Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

Get advil migraine liqui-gelshigher-rated option

Advertising disclosure: Some links are affiliate links. We may earn a commission at no extra cost to you. This never affects our independent ratings.

Where to buy

Buy over-the-counter from trusted retailers.

AmazonCheck price on Amazon

Frequently asked questions

Which is cheaper, Advil Migraine Liqui-Gels or Pennsaid?

Advil Migraine Liqui-Gels costs pharmacies less to acquire — about $0.04 vs $0.36 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Advil Migraine Liqui-Gels and Pennsaid?

Advil Migraine Liqui-Gels contains Ibuprofen, while Pennsaid contains Diclofenac Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.