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ADVIL CONGESTION RELIEF vs NAPROXEN SODIUM AND PSEUDOEPHEDRINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Rating

72/100
64/100

Pharmacy pays

$0.04 /mL
$0.06 /mL

Type

OTC
OTC

Active ingredient

IBUPROFEN AND PHENYLEPHRINE HYDROCHLORIDE
NAPROXEN SODIUM AND PSEUDOEPHEDRINE HYDROCHLORIDE

Dosage forms

Tablet
Tablet, Tablet, extended release, Multilayer, extended release

Drug class

Boxed warning

None
None

Half-life

about 1.8 to 2.0 hours
roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

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Where to buy

Buy over-the-counter from trusted retailers.

Frequently asked questions

Which is better-rated, Advil Congestion Relief or Naproxen Sodium and Pseudoephedrine Hydrochloride?

By our independent rating, Advil Congestion Relief scores higher — 3.6 vs 3.2 out of 5 for Naproxen Sodium and Pseudoephedrine Hydrochloride. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Advil Congestion Relief or Naproxen Sodium and Pseudoephedrine Hydrochloride?

Advil Congestion Relief costs pharmacies less to acquire — about $0.04 vs $0.06 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Advil Congestion Relief and Naproxen Sodium and Pseudoephedrine Hydrochloride?

Advil Congestion Relief contains Ibuprofen and Phenylephrine Hydrochloride, while Naproxen Sodium and Pseudoephedrine Hydrochloride contains Naproxen Sodium and Pseudoephedrine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.