ADVIL COLD AND SINUS vs SINE-AID IB

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Attribute	ADVIL COLD AND SINUS	SINE-AID IB
Rating	72/100	70/100
Pharmacy pays	$0.04 /mL	$0.04 /mL
Type	OTC	OTC
Active ingredient	IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE	IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE
Manufacturer	Haleon US Holdings	Kenvue Brands
Dosage forms	Capsule, Tablet	Tablet
Drug class	—	—
Boxed warning	None	None
Half-life	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

advil cold and sinus sine-aid ib

Rating

72/100

70/100

Pharmacy pays

$0.04 /mL

Type

OTC

Active ingredient

IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE

Manufacturer

Haleon US Holdings

Kenvue Brands

Dosage forms

Capsule, Tablet

Tablet

Drug class

—

Boxed warning

None

Half-life

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

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Where to buy

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Frequently asked questions

Which is better-rated, Advil Cold and Sinus or Sine-Aid Ib?

By our independent rating, Advil Cold and Sinus scores higher — 3.6 vs 3.5 out of 5 for Sine-Aid Ib. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Advil Cold and Sinus or Sine-Aid Ib?

Pharmacies pay about the same to acquire either one — roughly $0.04 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Advil Cold and Sinus and Sine-Aid Ib?

Both Advil Cold and Sinus and Sine-Aid Ib share the active ingredient Ibuprofen and Pseudoephedrine Hydrochloride.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.