ADVIL COLD AND SINUS vs PEPCID COMPLETE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Attribute	ADVIL COLD AND SINUS	PEPCID COMPLETE
Rating	72/100	70/100
Pharmacy pays	$0.04 /mL	~$0.24 /30
Type	OTC	OTC
Active ingredient	IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE	CALCIUM CARBONATE AND FAMOTIDINE AND MAGNESIUM HYDROXIDE
Manufacturer	Haleon US Holdings	Kenvue Brands
Dosage forms	Capsule, Tablet	Tablet, chewable
Drug class	—	—
Boxed warning	None	None
Half-life	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)	2.5 to 3.5 hours

advil cold and sinus pepcid complete

Rating

72/100

70/100

Pharmacy pays

$0.04 /mL

~$0.24 /30

Type

OTC

Active ingredient

IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE

CALCIUM CARBONATE AND FAMOTIDINE AND MAGNESIUM HYDROXIDE

Manufacturer

Haleon US Holdings

Kenvue Brands

Dosage forms

Capsule, Tablet

Tablet, chewable

Drug class

—

Boxed warning

None

Half-life

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

2.5 to 3.5 hours

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Frequently asked questions

Which is better-rated, Advil Cold and Sinus or Pepcid Complete?

By our independent rating, Advil Cold and Sinus scores higher — 3.6 vs 3.5 out of 5 for Pepcid Complete. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Advil Cold and Sinus and Pepcid Complete?

Advil Cold and Sinus contains Ibuprofen and Pseudoephedrine Hydrochloride, while Pepcid Complete contains Calcium Carbonate and Famotidine and Magnesium Hydroxide — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.