ADVIL COLD AND SINUS vs OPILL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Attribute	ADVIL COLD AND SINUS	OPILL
Rating	72/100	New
Pharmacy pays	$0.04 /mL	—
Type	OTC	OTC
Active ingredient	IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE	NORGESTREL
Manufacturer	Haleon US Holdings	Laboratoire Hra
Dosage forms	Capsule, Tablet	Tablet
Drug class	—	—
Boxed warning	None	None
Half-life	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)	—

advil cold and sinus opill

Rating

72/100

New

Pharmacy pays

$0.04 /mL

—

Type

OTC

Active ingredient

IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE

NORGESTREL

Manufacturer

Haleon US Holdings

Laboratoire Hra

Dosage forms

Capsule, Tablet

Tablet

Drug class

—

Boxed warning

None

Half-life

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

—

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Frequently asked questions

What is the difference between Advil Cold and Sinus and Opill?

Advil Cold and Sinus contains Ibuprofen and Pseudoephedrine Hydrochloride, while Opill contains Norgestrel — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.