ADVIL COLD AND SINUS vs VICKS NYQUIL COLD & FLU
Independent side-by-side comparison.
Rating
72/100
New
Pharmacy pays
$0.04 /mL
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Type
OTC
OTC
Active ingredient
IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE
Acetaminophen, dextromethorphan and doxylamine
Manufacturer
Dosage forms
Capsule, Tablet
Liquid
Drug class
—
—
Boxed warning
None
None
Half-life
roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)
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Get advil cold and sinushigher-rated option
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Where to buy
Buy over-the-counter from trusted retailers.
Frequently asked questions
What is the difference between Advil Cold and Sinus and Vicks Nyquil Cold & Flu?
Advil Cold and Sinus contains Ibuprofen and Pseudoephedrine Hydrochloride, while Vicks Nyquil Cold & Flu contains Acetaminophen, Dextromethorphan and Doxylamine — they have different active ingredients.
Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.