ADVIL COLD AND SINUS vs NAPROXEN SODIUM AND PSEUDOEPHEDRINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Attribute	ADVIL COLD AND SINUS	NAPROXEN SODIUM AND PSEUDOEPHEDRINE HYDROCHLORIDE
Rating	72/100	64/100
Pharmacy pays	$0.04 /mL	$0.06 /mL
Type	OTC	OTC
Active ingredient	IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE	NAPROXEN SODIUM AND PSEUDOEPHEDRINE HYDROCHLORIDE
Manufacturer	Haleon US Holdings	Perrigo
Dosage forms	Capsule, Tablet	Tablet, Tablet, extended release, Multilayer, extended release
Drug class	—	—
Boxed warning	None	None
Half-life	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

advil cold and sinus naproxen sodium and pseudoephedrine hydrochloride

Rating

72/100

64/100

Pharmacy pays

$0.04 /mL

$0.06 /mL

Type

OTC

Active ingredient

IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE

NAPROXEN SODIUM AND PSEUDOEPHEDRINE HYDROCHLORIDE

Manufacturer

Haleon US Holdings

Perrigo

Dosage forms

Capsule, Tablet

Tablet, Tablet, extended release, Multilayer, extended release

Drug class

—

Boxed warning

None

Half-life

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

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Frequently asked questions

Which is better-rated, Advil Cold and Sinus or Naproxen Sodium and Pseudoephedrine Hydrochloride?

By our independent rating, Advil Cold and Sinus scores higher — 3.6 vs 3.2 out of 5 for Naproxen Sodium and Pseudoephedrine Hydrochloride. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Advil Cold and Sinus or Naproxen Sodium and Pseudoephedrine Hydrochloride?

Advil Cold and Sinus costs pharmacies less to acquire — about $0.04 vs $0.06 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Advil Cold and Sinus and Naproxen Sodium and Pseudoephedrine Hydrochloride?

Advil Cold and Sinus contains Ibuprofen and Pseudoephedrine Hydrochloride, while Naproxen Sodium and Pseudoephedrine Hydrochloride contains Naproxen Sodium and Pseudoephedrine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.