ADVIL COLD AND SINUS vs MUCINEX DM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Attribute	ADVIL COLD AND SINUS	MUCINEX DM
Rating	72/100	New
Pharmacy pays	$0.04 /mL	~$2.55 /30
Type	OTC	OTC
Active ingredient	IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE	DEXTROMETHORPHAN HYDROBROMIDE AND GUAIFENESIN
Manufacturer	Haleon US Holdings	Rb Hlth
Dosage forms	Capsule, Tablet	Tablet, extended release
Drug class	—	—
Boxed warning	None	None
Half-life	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)	—

advil cold and sinus mucinex dm

Rating

72/100

New

Pharmacy pays

$0.04 /mL

~$2.55 /30

Type

OTC

Active ingredient

IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE

DEXTROMETHORPHAN HYDROBROMIDE AND GUAIFENESIN

Manufacturer

Haleon US Holdings

Rb Hlth

Dosage forms

Capsule, Tablet

Tablet, extended release

Drug class

—

Boxed warning

None

Half-life

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

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Frequently asked questions

What is the difference between Advil Cold and Sinus and Mucinex Dm?

Advil Cold and Sinus contains Ibuprofen and Pseudoephedrine Hydrochloride, while Mucinex Dm contains Dextromethorphan Hydrobromide and Guaifenesin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.