ADVIL COLD AND SINUS vs MUCINEX D

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Attribute	ADVIL COLD AND SINUS	MUCINEX D
Rating	72/100	New
Pharmacy pays	$0.04 /mL	$0.07 /mL
Type	OTC	OTC
Active ingredient	IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE	GUAIFENESIN AND PSEUDOEPHEDRINE HYDROCHLORIDE
Manufacturer	Haleon US Holdings	Rb Hlth
Dosage forms	Capsule, Tablet	Tablet, extended release
Drug class	—	—
Boxed warning	None	None
Half-life	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

advil cold and sinus mucinex d

Rating

72/100

New

Pharmacy pays

$0.04 /mL

$0.07 /mL

Type

OTC

Active ingredient

IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE

GUAIFENESIN AND PSEUDOEPHEDRINE HYDROCHLORIDE

Manufacturer

Haleon US Holdings

Rb Hlth

Dosage forms

Capsule, Tablet

Tablet, extended release

Drug class

—

Boxed warning

None

Half-life

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

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Frequently asked questions

Which is cheaper, Advil Cold and Sinus or Mucinex D?

Advil Cold and Sinus costs pharmacies less to acquire — about $0.04 vs $0.07 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Advil Cold and Sinus and Mucinex D?

Advil Cold and Sinus contains Ibuprofen and Pseudoephedrine Hydrochloride, while Mucinex D contains Guaifenesin and Pseudoephedrine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.