ADVIL COLD AND SINUS vs ADVIL CONGESTION RELIEF

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Attribute	ADVIL COLD AND SINUS	ADVIL CONGESTION RELIEF
Rating	72/100	72/100
Pharmacy pays	$0.04 /mL	$0.04 /mL
Type	OTC	OTC
Active ingredient	IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE	IBUPROFEN AND PHENYLEPHRINE HYDROCHLORIDE
Manufacturer	Haleon US Holdings	Haleon US Holdings
Dosage forms	Capsule, Tablet	Tablet
Drug class	—	—
Boxed warning	None	None
Half-life	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)	about 1.8 to 2.0 hours

advil cold and sinus advil congestion relief

Rating

72/100

Pharmacy pays

$0.04 /mL

Type

OTC

Active ingredient

IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE

IBUPROFEN AND PHENYLEPHRINE HYDROCHLORIDE

Manufacturer

Haleon US Holdings

Dosage forms

Capsule, Tablet

Tablet

Drug class

—

Boxed warning

None

Half-life

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

about 1.8 to 2.0 hours

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Where to buy

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Frequently asked questions

Which is better-rated, Advil Cold and Sinus or Advil Congestion Relief?

Advil Cold and Sinus and Advil Congestion Relief are tied at 3.6 out of 5 by our independent rating.

Which is cheaper, Advil Cold and Sinus or Advil Congestion Relief?

Pharmacies pay about the same to acquire either one — roughly $0.04 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Advil Cold and Sinus and Advil Congestion Relief?

Advil Cold and Sinus contains Ibuprofen and Pseudoephedrine Hydrochloride, while Advil Congestion Relief contains Ibuprofen and Phenylephrine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.