ADVIL ALLERGY SINUS vs MUCINEX DM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Attribute	ADVIL ALLERGY SINUS	MUCINEX DM
Rating	72/100	New
Pharmacy pays	—	~$2.55 /30
Type	OTC	OTC
Active ingredient	CHLORPHENIRAMINE MALEATE AND IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE	DEXTROMETHORPHAN HYDROBROMIDE AND GUAIFENESIN
Manufacturer	Haleon US Holdings	Rb Hlth
Dosage forms	Tablet	Tablet, extended release
Drug class	—	—
Boxed warning	None	None
Half-life	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)	—

advil allergy sinus mucinex dm

Rating

72/100

New

Pharmacy pays

—

~$2.55 /30

Type

OTC

Active ingredient

CHLORPHENIRAMINE MALEATE AND IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE

DEXTROMETHORPHAN HYDROBROMIDE AND GUAIFENESIN

Manufacturer

Haleon US Holdings

Rb Hlth

Dosage forms

Tablet

Tablet, extended release

Drug class

—

Boxed warning

None

Half-life

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

—

Get advil allergy sinushigher-rated option

Advertising disclosure: Some links are affiliate links. We may earn a commission at no extra cost to you. This never affects our independent ratings.

Where to buy

Buy over-the-counter from trusted retailers.

AmazonCheck price on Amazon

Frequently asked questions

What is the difference between Advil Allergy Sinus and Mucinex Dm?

Advil Allergy Sinus contains Chlorpheniramine Maleate and Ibuprofen and Pseudoephedrine Hydrochloride, while Mucinex Dm contains Dextromethorphan Hydrobromide and Guaifenesin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.