ADVIL ALLERGY SINUS vs ADVIL PM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Attribute	ADVIL ALLERGY SINUS	ADVIL PM
Rating	72/100	72/100
Pharmacy pays	—	$0.04 /mL
Type	OTC	OTC
Active ingredient	CHLORPHENIRAMINE MALEATE AND IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE	DIPHENHYDRAMINE HYDROCHLORIDE AND IBUPROFEN
Manufacturer	Haleon US Holdings	Haleon US Holdings
Dosage forms	Tablet	Capsule, Tablet
Drug class	—	—
Boxed warning	None	None
Half-life	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)	about 1.8 to 2.0 hours

advil allergy sinus advil pm

Rating

72/100

Pharmacy pays

—

$0.04 /mL

Type

OTC

Active ingredient

CHLORPHENIRAMINE MALEATE AND IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE

DIPHENHYDRAMINE HYDROCHLORIDE AND IBUPROFEN

Manufacturer

Haleon US Holdings

Dosage forms

Tablet

Capsule, Tablet

Drug class

—

Boxed warning

None

Half-life

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

about 1.8 to 2.0 hours

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Frequently asked questions

Which is better-rated, Advil Allergy Sinus or Advil Pm?

Advil Allergy Sinus and Advil Pm are tied at 3.6 out of 5 by our independent rating.

What is the difference between Advil Allergy Sinus and Advil Pm?

Advil Allergy Sinus contains Chlorpheniramine Maleate and Ibuprofen and Pseudoephedrine Hydrochloride, while Advil Pm contains Diphenhydramine Hydrochloride and Ibuprofen — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.