ADVIL ALLERGY SINUS vs ADVIL CONGESTION RELIEF

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Attribute	ADVIL ALLERGY SINUS	ADVIL CONGESTION RELIEF
Rating	72/100	72/100
Pharmacy pays	—	$0.04 /mL
Type	OTC	OTC
Active ingredient	CHLORPHENIRAMINE MALEATE AND IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE	IBUPROFEN AND PHENYLEPHRINE HYDROCHLORIDE
Manufacturer	Haleon US Holdings	Haleon US Holdings
Dosage forms	Tablet	Tablet
Drug class	—	—
Boxed warning	None	None
Half-life	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)	about 1.8 to 2.0 hours

advil allergy sinus advil congestion relief

Rating

72/100

Pharmacy pays

—

$0.04 /mL

Type

OTC

Active ingredient

CHLORPHENIRAMINE MALEATE AND IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE

IBUPROFEN AND PHENYLEPHRINE HYDROCHLORIDE

Manufacturer

Haleon US Holdings

Dosage forms

Tablet

Drug class

—

Boxed warning

None

Half-life

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

about 1.8 to 2.0 hours

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Frequently asked questions

Which is better-rated, Advil Allergy Sinus or Advil Congestion Relief?

Advil Allergy Sinus and Advil Congestion Relief are tied at 3.6 out of 5 by our independent rating.

What is the difference between Advil Allergy Sinus and Advil Congestion Relief?

Advil Allergy Sinus contains Chlorpheniramine Maleate and Ibuprofen and Pseudoephedrine Hydrochloride, while Advil Congestion Relief contains Ibuprofen and Phenylephrine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.