ACZONE vs METHYLPREDNISOLONE ACETATE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. ACZONE and METHYLPREDNISOLONE ACETATE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ACZONE	METHYLPREDNISOLONE ACETATE
Rating	New	70/100
Pharmacy pays	~$23.83 /30	~$30.69 /30
Type	RX	RX
Active ingredient	DAPSONE	METHYLPREDNISOLONE ACETATE
Manufacturer	Almirall	Amneal
Dosage forms	Topical	Injectable
Drug class	Sulfone	Corticosteroid
Boxed warning	None	None
Treats	Dermatitis Herpetiformis, Relapsing Polychondritis, Lepromatous Leprosy	Adrenal Insufficiency, Asthma, Berylliosis

aczone methylprednisolone acetate

Rating

New

70/100

Pharmacy pays

~$23.83 /30

~$30.69 /30

Type

Active ingredient

DAPSONE

METHYLPREDNISOLONE ACETATE

Manufacturer

Almirall

Amneal

Dosage forms

Topical

Injectable

Drug class

Sulfone

Corticosteroid

Boxed warning

None

Treats

Dermatitis Herpetiformis, Relapsing Polychondritis, Lepromatous Leprosy

Adrenal Insufficiency, Asthma, Berylliosis

Frequently asked questions

Which is cheaper, Aczone or Methylprednisolone Acetate?

Aczone costs pharmacies less to acquire — about $23.83 vs $30.69 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Aczone and Methylprednisolone Acetate?

Aczone contains Dapsone, while Methylprednisolone Acetate contains Methylprednisolone Acetate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.