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ACZONE vs METHYLPREDNISOLONE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. ACZONE and METHYLPREDNISOLONE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
70/100

Pharmacy pays

~$23.83 /30
~$30.69 /30

Type

RX
RX

Active ingredient

DAPSONE
METHYLPREDNISOLONE

Dosage forms

Topical
Tablet

Drug class

Sulfone
Corticosteroid

Boxed warning

None
None

Treats

Dermatitis Herpetiformis, Relapsing Polychondritis, Lepromatous Leprosy
Adrenal Insufficiency, Asthma, Berylliosis

Get methylprednisolonehigher-rated option

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Frequently asked questions

Which is cheaper, Aczone or Methylprednisolone?

Aczone costs pharmacies less to acquire — about $23.83 vs $30.69 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Aczone and Methylprednisolone?

Aczone contains Dapsone, while Methylprednisolone contains Methylprednisolone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.