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ACYCLOVIR vs ACYCLOVIR SODIUM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. ACYCLOVIR and ACYCLOVIR SODIUM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

56/100
70/100

Pharmacy pays

~$4.83 /30
~$4.83 /30

Type

RX
RX

Active ingredient

ACYCLOVIR
ACYCLOVIR SODIUM

Manufacturer

Dosage forms

Topical, Capsule, Injectable, Solution, Suspension, Tablet
Injectable

Drug class

Herpes Simplex Virus Nucleoside Analog Dna Polymerase Inhibitor
Herpes Simplex Virus Nucleoside Analog Dna Polymerase Inhibitor

Boxed warning

None
None

Half-life

about 2.5 to 3.3 hours
about 2.5 to 3.3 hours

Treats

Chickenpox, Herpes Genitalis, Herpes Labialis
Chickenpox, Herpes Genitalis, Herpes Labialis

Frequently asked questions

Which is better-rated, Acyclovir or Acyclovir Sodium?

By our independent rating, Acyclovir Sodium scores higher — 3.5 vs 2.8 out of 5 for Acyclovir. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Acyclovir or Acyclovir Sodium?

Pharmacies pay about the same to acquire either one — roughly $4.83 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Acyclovir and Acyclovir Sodium?

Acyclovir contains Acyclovir, while Acyclovir Sodium contains Acyclovir Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.