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ACYCLOVIR SODIUM vs AVACLYR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. ACYCLOVIR SODIUM and AVACLYR are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

70/100
New

Pharmacy pays

~$4.83 /30
~$4.83 /30

Type

RX
RX

Active ingredient

ACYCLOVIR SODIUM
ACYCLOVIR

Dosage forms

Injectable
Topical

Drug class

Herpes Simplex Virus Nucleoside Analog Dna Polymerase Inhibitor
Herpes Simplex Virus Nucleoside Analog Dna Polymerase Inhibitor

Boxed warning

None
None

Half-life

about 2.5 to 3.3 hours
about 2.5 to 3.3 hours

Treats

Chickenpox, Herpes Genitalis, Herpes Labialis
Chickenpox, Herpes Genitalis, Herpes Labialis

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Frequently asked questions

Which is cheaper, Acyclovir Sodium or Avaclyr?

Pharmacies pay about the same to acquire either one — roughly $4.83 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Acyclovir Sodium and Avaclyr?

Acyclovir Sodium contains Acyclovir Sodium, while Avaclyr contains Acyclovir — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.