ACULAR vs PREMPHASE (PREMARIN;CYCRIN 14/14)

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Possible drug interaction. ACULAR and PREMPHASE (PREMARIN;CYCRIN 14/14) are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ACULAR	PREMPHASE (PREMARIN;CYCRIN 14/14)
Rating	72/100	New
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	KETOROLAC TROMETHAMINE	ESTROGENS, CONJUGATED AND MEDROXYPROGESTERONE ACETATE
Manufacturer	Abbvie	Wyeth Pharms Inc
Dosage forms	Drops	Tablet
Drug class	Nonsteroidal Anti-Inflammatory Drug	—
Boxed warning	None	None
Half-life	about 5 to 6 hours	—
Treats	Allergic Conjunctivitis, Inflammation, Pain	—

acular premphase (premarin;cycrin 14/14)

Rating

72/100

New

Pharmacy pays

—

Type

Active ingredient

KETOROLAC TROMETHAMINE

ESTROGENS, CONJUGATED AND MEDROXYPROGESTERONE ACETATE

Manufacturer

Abbvie

Wyeth Pharms Inc

Dosage forms

Drops

Tablet

Drug class

Nonsteroidal Anti-Inflammatory Drug

—

Boxed warning

None

Half-life

about 5 to 6 hours

—

Treats

Allergic Conjunctivitis, Inflammation, Pain

—

Frequently asked questions

What is the difference between Acular and Premphase (Premarin;Cycrin 14/14)?

Acular contains Ketorolac Tromethamine, while Premphase (Premarin;Cycrin 14/14) contains Estrogens, Conjugated and Medroxyprogesterone Acetate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.