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ACULAR vs HISTAFED

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. ACULAR and HISTAFED are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

72/100
New

Pharmacy pays

~$8.29 /30

Type

RX
RX

Active ingredient

KETOROLAC TROMETHAMINE
PSEUDOEPHEDRINE HYDROCHLORIDE AND TRIPROLIDINE HYDROCHLORIDE

Manufacturer

Dosage forms

Drops
Syrup

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None
None

Half-life

about 5 to 6 hours
roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

Treats

Allergic Conjunctivitis, Inflammation, Pain

Frequently asked questions

What is the difference between Acular and Histafed?

Acular contains Ketorolac Tromethamine, while Histafed contains Pseudoephedrine Hydrochloride and Triprolidine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.