ACULAR LS vs SMOFLIPID 20%

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. ACULAR LS and SMOFLIPID 20% are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ACULAR LS	SMOFLIPID 20%
Rating	72/100	68/100
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	KETOROLAC TROMETHAMINE	FISH OIL AND MEDIUM CHAIN TRIGLYCERIDES AND OLIVE OIL AND SOYBEAN OIL
Manufacturer	Abbvie	Fresenius Kabi USA
Dosage forms	Drops	Injectable, Emulsion
Drug class	Nonsteroidal Anti-Inflammatory Drug	—
Boxed warning	None	None
Half-life	about 5 to 6 hours	—
Treats	Allergic Conjunctivitis, Inflammation, Pain	—

acular ls smoflipid 20%

Rating

72/100

68/100

Pharmacy pays

—

Type

Active ingredient

KETOROLAC TROMETHAMINE

FISH OIL AND MEDIUM CHAIN TRIGLYCERIDES AND OLIVE OIL AND SOYBEAN OIL

Manufacturer

Abbvie

Fresenius Kabi USA

Dosage forms

Drops

Injectable, Emulsion

Drug class

Nonsteroidal Anti-Inflammatory Drug

—

Boxed warning

None

Half-life

about 5 to 6 hours

—

Treats

Allergic Conjunctivitis, Inflammation, Pain

—

Frequently asked questions

Which is better-rated, Acular Ls or Smoflipid 20%?

By our independent rating, Acular Ls scores higher — 3.6 vs 3.4 out of 5 for Smoflipid 20%. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Acular Ls and Smoflipid 20%?

Acular Ls contains Ketorolac Tromethamine, while Smoflipid 20% contains Fish Oil and Medium Chain Triglycerides and Olive Oil and Soybean Oil — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.