ACULAR LS vs SEMPREX-D

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Possible drug interaction. ACULAR LS and SEMPREX-D are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ACULAR LS	SEMPREX-D
Rating	72/100	New
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	KETOROLAC TROMETHAMINE	ACRIVASTINE AND PSEUDOEPHEDRINE HYDROCHLORIDE
Manufacturer	Abbvie	Endo Operations
Dosage forms	Drops	Capsule
Drug class	Nonsteroidal Anti-Inflammatory Drug	—
Boxed warning	None	None
Half-life	about 5 to 6 hours	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)
Treats	Allergic Conjunctivitis, Inflammation, Pain	—

acular ls semprex-d

Rating

72/100

New

Pharmacy pays

—

Type

Active ingredient

KETOROLAC TROMETHAMINE

ACRIVASTINE AND PSEUDOEPHEDRINE HYDROCHLORIDE

Manufacturer

Abbvie

Endo Operations

Dosage forms

Drops

Capsule

Drug class

Nonsteroidal Anti-Inflammatory Drug

—

Boxed warning

None

Half-life

about 5 to 6 hours

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

Treats

Allergic Conjunctivitis, Inflammation, Pain

—

Frequently asked questions

What is the difference between Acular Ls and Semprex-D?

Acular Ls contains Ketorolac Tromethamine, while Semprex-D contains Acrivastine and Pseudoephedrine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.