ACULAR LS vs PREFRIN-A

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. ACULAR LS and PREFRIN-A are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ACULAR LS	PREFRIN-A
Rating	72/100	72/100
Pharmacy pays	—	$8.59 /mL
Type	RX	RX
Active ingredient	KETOROLAC TROMETHAMINE	PHENYLEPHRINE HYDROCHLORIDE AND PYRILAMINE MALEATE
Manufacturer	Abbvie	Allergan
Dosage forms	Drops	Drops
Drug class	Nonsteroidal Anti-Inflammatory Drug	—
Boxed warning	None	None
Half-life	about 5 to 6 hours	—
Treats	Allergic Conjunctivitis, Inflammation, Pain	—

acular ls prefrin-a

Rating

72/100

Pharmacy pays

—

$8.59 /mL

Type

Active ingredient

KETOROLAC TROMETHAMINE

PHENYLEPHRINE HYDROCHLORIDE AND PYRILAMINE MALEATE

Manufacturer

Abbvie

Allergan

Dosage forms

Drops

Drug class

Nonsteroidal Anti-Inflammatory Drug

—

Boxed warning

None

Half-life

about 5 to 6 hours

—

Treats

Allergic Conjunctivitis, Inflammation, Pain

—

Frequently asked questions

Which is better-rated, Acular Ls or Prefrin-A?

Acular Ls and Prefrin-A are tied at 3.6 out of 5 by our independent rating.

What is the difference between Acular Ls and Prefrin-A?

Acular Ls contains Ketorolac Tromethamine, while Prefrin-A contains Phenylephrine Hydrochloride and Pyrilamine Maleate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.