ACULAR LS vs ISOPAQUE 440

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 12, 2026·How we rate

Possible drug interaction. ACULAR LS and ISOPAQUE 440 are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ACULAR LS	ISOPAQUE 440
Rating	72/100	New
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	KETOROLAC TROMETHAMINE	CALCIUM METRIZOATE AND MEGLUMINE METRIZOATE AND METRIZOATE MAGNESIUM AND METRIZOATE SODIUM
Manufacturer	Abbvie	Ge Healthcare
Dosage forms	Drops	Injectable
Drug class	Nonsteroidal Anti-Inflammatory Drug	—
Boxed warning	None	None
Half-life	about 5 to 6 hours	—
Treats	Allergic Conjunctivitis, Inflammation, Pain	—

acular ls isopaque 440

Rating

72/100

New

Pharmacy pays

—

Type

Active ingredient

KETOROLAC TROMETHAMINE

CALCIUM METRIZOATE AND MEGLUMINE METRIZOATE AND METRIZOATE MAGNESIUM AND METRIZOATE SODIUM

Manufacturer

Abbvie

Ge Healthcare

Dosage forms

Drops

Injectable

Drug class

Nonsteroidal Anti-Inflammatory Drug

—

Boxed warning

None

Half-life

about 5 to 6 hours

—

Treats

Allergic Conjunctivitis, Inflammation, Pain

—

Frequently asked questions

What is the difference between Acular Ls and Isopaque 440?

Acular Ls contains Ketorolac Tromethamine, while Isopaque 440 contains Calcium Metrizoate and Meglumine Metrizoate and Metrizoate Magnesium and Metrizoate Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.