ACULAR LS vs COMBIPRES

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 12, 2026·How we rate

Possible drug interaction. ACULAR LS and COMBIPRES are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ACULAR LS	COMBIPRES
Rating	72/100	72/100
Pharmacy pays	—	~$2.67 /30
Type	RX	RX
Active ingredient	KETOROLAC TROMETHAMINE	CHLORTHALIDONE AND CLONIDINE HYDROCHLORIDE
Manufacturer	Abbvie	Boehringer Ingelheim
Dosage forms	Drops	Tablet
Drug class	Nonsteroidal Anti-Inflammatory Drug	—
Boxed warning	None	None
Half-life	about 5 to 6 hours	about 40 hours on average (the label reports a mean half-life of 40 hours after a 50–200 mg dose, and an elimination half-life of 53 hours after 50 mg and 60 hours after 100 mg)
Treats	Allergic Conjunctivitis, Inflammation, Pain	—

acular ls combipres

Rating

72/100

Pharmacy pays

—

~$2.67 /30

Type

Active ingredient

KETOROLAC TROMETHAMINE

CHLORTHALIDONE AND CLONIDINE HYDROCHLORIDE

Manufacturer

Abbvie

Boehringer Ingelheim

Dosage forms

Drops

Tablet

Drug class

Nonsteroidal Anti-Inflammatory Drug

—

Boxed warning

None

Half-life

about 5 to 6 hours

about 40 hours on average (the label reports a mean half-life of 40 hours after a 50–200 mg dose, and an elimination half-life of 53 hours after 50 mg and 60 hours after 100 mg)

Treats

Allergic Conjunctivitis, Inflammation, Pain

—

Frequently asked questions

Which is better-rated, Acular Ls or Combipres?

Acular Ls and Combipres are tied at 3.6 out of 5 by our independent rating.

What is the difference between Acular Ls and Combipres?

Acular Ls contains Ketorolac Tromethamine, while Combipres contains Chlorthalidone and Clonidine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.