ACTOPLUS MET vs CUPRIMINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 7, 2026·How we rate

Possible drug interaction. ACTOPLUS MET and CUPRIMINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ACTOPLUS MET	CUPRIMINE
Rating	New	74/100
Pharmacy pays	~$0.74 /30	—
Type	RX	RX
Active ingredient	METFORMIN HYDROCHLORIDE AND PIOGLITAZONE HYDROCHLORIDE	PENICILLAMINE
Manufacturer	Takeda Pharms USA	Valeant Pharm Intl
Dosage forms	Tablet	Capsule
Drug class	—	Antirheumatic Agent
Boxed warning	Boxed warning	Boxed warning
Half-life	about 3 to 7 hours (parent drug)	—
Treats	—	Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration

actoplus met cuprimine

Rating

New

74/100

Pharmacy pays

~$0.74 /30

—

Type

Active ingredient

METFORMIN HYDROCHLORIDE AND PIOGLITAZONE HYDROCHLORIDE

PENICILLAMINE

Manufacturer

Takeda Pharms USA

Valeant Pharm Intl

Dosage forms

Tablet

Capsule

Drug class

—

Antirheumatic Agent

Boxed warning

Half-life

about 3 to 7 hours (parent drug)

—

Treats

—

Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration

Frequently asked questions

What is the difference between Actoplus Met and Cuprimine?

Actoplus Met contains Metformin Hydrochloride and Pioglitazone Hydrochloride, while Cuprimine contains Penicillamine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.