ACTOPLUS MET vs COLAZAL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 7, 2026·How we rate

Possible drug interaction. ACTOPLUS MET and COLAZAL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ACTOPLUS MET	COLAZAL
Rating	New	74/100
Pharmacy pays	~$0.74 /30	~$11.02 /30
Type	RX	RX
Active ingredient	METFORMIN HYDROCHLORIDE AND PIOGLITAZONE HYDROCHLORIDE	BALSALAZIDE DISODIUM
Manufacturer	Takeda Pharms USA	Valeant Pharm Intl
Dosage forms	Tablet	Capsule
Drug class	—	Aminosalicylate
Boxed warning	Boxed warning	None
Half-life	about 3 to 7 hours (parent drug)	—
Treats	—	Ulcerative Colitis

actoplus met colazal

Rating

New

74/100

Pharmacy pays

~$0.74 /30

~$11.02 /30

Type

Active ingredient

METFORMIN HYDROCHLORIDE AND PIOGLITAZONE HYDROCHLORIDE

BALSALAZIDE DISODIUM

Manufacturer

Takeda Pharms USA

Valeant Pharm Intl

Dosage forms

Tablet

Capsule

Drug class

—

Aminosalicylate

Boxed warning

None

Half-life

about 3 to 7 hours (parent drug)

—

Treats

—

Ulcerative Colitis

Frequently asked questions

Which is cheaper, Actoplus Met or Colazal?

Actoplus Met costs pharmacies less to acquire — about $0.74 vs $11.02 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Actoplus Met and Colazal?

Actoplus Met contains Metformin Hydrochloride and Pioglitazone Hydrochloride, while Colazal contains Balsalazide Disodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.