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ACTIQ vs METHADONE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. ACTIQ and METHADONE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
72/100

Pharmacy pays

$9.51 /mL
$0.18 /mL

Type

RX
RX

Active ingredient

FENTANYL CITRATE
METHADONE HYDROCHLORIDE

Manufacturer

Dosage forms

Lozenge
Injectable, Solution, Tablet

Drug class

Opioid Agonist
Opioid Agonist

Half-life

about 8 to 59 hours (terminal/elimination half-life; a very wide range)

Treats

Pain
Opioid-Related Disorders, Intractable Pain

Frequently asked questions

Which is cheaper, Actiq or Methadone Hydrochloride?

Methadone Hydrochloride costs pharmacies less to acquire — about $0.18 vs $9.51 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Actiq and Methadone Hydrochloride?

Actiq contains Fentanyl Citrate, while Methadone Hydrochloride contains Methadone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.