ACTIFED vs HISTAFED
Independent side-by-side comparison.
Rating
70/100
New
Pharmacy pays
~$8.29 /30
~$8.29 /30
Type
RX
RX
Active ingredient
PSEUDOEPHEDRINE HYDROCHLORIDE AND TRIPROLIDINE HYDROCHLORIDE
PSEUDOEPHEDRINE HYDROCHLORIDE AND TRIPROLIDINE HYDROCHLORIDE
Manufacturer
Dosage forms
Tablet
Syrup
Drug class
—
—
Boxed warning
None
None
Half-life
roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)
roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)
Frequently asked questions
Which is cheaper, Actifed or Histafed?
Pharmacies pay about the same to acquire either one — roughly $8.29 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.
What is the difference between Actifed and Histafed?
Both Actifed and Histafed share the active ingredient Pseudoephedrine Hydrochloride and Triprolidine Hydrochloride.
Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.