ACTIFED vs ACULAR LS

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. ACTIFED and ACULAR LS are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ACTIFED	ACULAR LS
Rating	70/100	72/100
Pharmacy pays	~$8.29 /30	—
Type	RX	RX
Active ingredient	PSEUDOEPHEDRINE HYDROCHLORIDE AND TRIPROLIDINE HYDROCHLORIDE	KETOROLAC TROMETHAMINE
Manufacturer	Glaxosmithkline	Abbvie
Dosage forms	Tablet	Drops
Drug class	—	Nonsteroidal Anti-Inflammatory Drug
Boxed warning	None	None
Half-life	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)	about 5 to 6 hours
Treats	—	Allergic Conjunctivitis, Inflammation, Pain

actifed acular ls

Rating

70/100

72/100

Pharmacy pays

~$8.29 /30

—

Type

Active ingredient

PSEUDOEPHEDRINE HYDROCHLORIDE AND TRIPROLIDINE HYDROCHLORIDE

KETOROLAC TROMETHAMINE

Manufacturer

Glaxosmithkline

Abbvie

Dosage forms

Tablet

Drops

Drug class

—

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None

Half-life

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

about 5 to 6 hours

Treats

—

Allergic Conjunctivitis, Inflammation, Pain

Frequently asked questions

Which is better-rated, Actifed or Acular Ls?

By our independent rating, Acular Ls scores higher — 3.6 vs 3.5 out of 5 for Actifed. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Actifed and Acular Ls?

Actifed contains Pseudoephedrine Hydrochloride and Triprolidine Hydrochloride, while Acular Ls contains Ketorolac Tromethamine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.