ACIPHEX vs PRILOSEC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. ACIPHEX and PRILOSEC are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ACIPHEX	PRILOSEC
Rating	New	70/100
Pharmacy pays	—	~$1.52 /30
Type	RX	RX
Active ingredient	RABEPRAZOLE SODIUM	OMEPRAZOLE
Manufacturer	Eisai Medcl Res	Astrazeneca
Dosage forms	Tablet, delayed release	Powder, delayed release
Drug class	Proton Pump Inhibitor	Proton Pump Inhibitor
Boxed warning	None	None
Half-life	—	about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults
Treats	Duodenal Ulcer, Gastroesophageal Reflux, Heartburn	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

aciphex prilosec

Rating

New

70/100

Pharmacy pays

—

~$1.52 /30

Type

Active ingredient

RABEPRAZOLE SODIUM

OMEPRAZOLE

Manufacturer

Eisai Medcl Res

Astrazeneca

Dosage forms

Tablet, delayed release

Powder, delayed release

Drug class

Proton Pump Inhibitor

Boxed warning

None

Half-life

—

about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults

Treats

Duodenal Ulcer, Gastroesophageal Reflux, Heartburn

Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

Get prilosechigher-rated option

Advertising disclosure: Some links are affiliate links. We may earn a commission at no extra cost to you. This never affects our independent ratings.

Get treatment online

Licensed online providers — consult & get prescribed if eligible.

SesameCompare online visit prices

Frequently asked questions

What is the difference between Aciphex and Prilosec?

Aciphex contains Rabeprazole Sodium, while Prilosec contains Omeprazole — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.