ACIPHEX vs NEXIUM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. ACIPHEX and NEXIUM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ACIPHEX	NEXIUM
Rating	New	70/100
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	RABEPRAZOLE SODIUM	ESOMEPRAZOLE MAGNESIUM
Manufacturer	Eisai Medcl Res	Astrazeneca
Dosage forms	Tablet, delayed release	Capsule, delayed release, Powder, delayed release
Drug class	Proton Pump Inhibitor	Proton Pump Inhibitor
Boxed warning	None	None
Treats	Duodenal Ulcer, Gastroesophageal Reflux, Heartburn	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

aciphex nexium

Rating

New

70/100

Pharmacy pays

—

Type

Active ingredient

RABEPRAZOLE SODIUM

ESOMEPRAZOLE MAGNESIUM

Manufacturer

Eisai Medcl Res

Astrazeneca

Dosage forms

Tablet, delayed release

Capsule, delayed release, Powder, delayed release

Drug class

Proton Pump Inhibitor

Boxed warning

None

Treats

Duodenal Ulcer, Gastroesophageal Reflux, Heartburn

Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

Get nexiumhigher-rated option

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Frequently asked questions

What is the difference between Aciphex and Nexium?

Aciphex contains Rabeprazole Sodium, while Nexium contains Esomeprazole Magnesium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.