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ACEPHEN vs TYLENOL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Rating

70/100
70/100

Pharmacy pays

$0.03 /mL
$0.03 /mL

Type

RX
OTC

Active ingredient

ACETAMINOPHEN
ACETAMINOPHEN

Dosage forms

Suppository
Tablet, extended release

Drug class

Boxed warning

None
None

Treats

Fever, Pain
Fever, Pain

Get tylenol

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Where to buy

Buy over-the-counter from trusted retailers.

Frequently asked questions

Which is better-rated, Acephen or Tylenol?

Acephen and Tylenol are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Acephen or Tylenol?

Pharmacies pay about the same to acquire either one — roughly $0.03 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Acephen and Tylenol?

Both Acephen and Tylenol share the active ingredient Acetaminophen, but Acephen is sold as RX and Tylenol as OTC.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.