ABREVA vs NAPROXEN SODIUM AND PSEUDOEPHEDRINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 15, 2026·How we rate

Attribute	ABREVA	NAPROXEN SODIUM AND PSEUDOEPHEDRINE HYDROCHLORIDE
Rating	72/100	64/100
Pharmacy pays	$6.64 /g	$0.06 /mL
Type	OTC	OTC
Active ingredient	DOCOSANOL	NAPROXEN SODIUM AND PSEUDOEPHEDRINE HYDROCHLORIDE
Manufacturer	Haleon US Holdings	Perrigo
Dosage forms	Topical	Tablet, Tablet, extended release, Multilayer, extended release
Drug class	—	—
Boxed warning	None	None
Half-life	—	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)
Treats	Blister	—

abreva naproxen sodium and pseudoephedrine hydrochloride

Rating

72/100

64/100

Pharmacy pays

$6.64 /g

$0.06 /mL

Type

OTC

Active ingredient

DOCOSANOL

NAPROXEN SODIUM AND PSEUDOEPHEDRINE HYDROCHLORIDE

Manufacturer

Haleon US Holdings

Perrigo

Dosage forms

Topical

Tablet, Tablet, extended release, Multilayer, extended release

Drug class

—

Boxed warning

None

Half-life

—

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

Treats

Blister

—

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Frequently asked questions

Which is better-rated, Abreva or Naproxen Sodium and Pseudoephedrine Hydrochloride?

By our independent rating, Abreva scores higher — 3.6 vs 3.2 out of 5 for Naproxen Sodium and Pseudoephedrine Hydrochloride. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Abreva and Naproxen Sodium and Pseudoephedrine Hydrochloride?

Abreva contains Docosanol, while Naproxen Sodium and Pseudoephedrine Hydrochloride contains Naproxen Sodium and Pseudoephedrine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.