ABREVA vs ADVIL COLD AND SINUS

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Attribute	ABREVA	ADVIL COLD AND SINUS
Rating	72/100	72/100
Pharmacy pays	$6.64 /g	$0.04 /mL
Type	OTC	OTC
Active ingredient	DOCOSANOL	IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE
Manufacturer	Haleon US Holdings	Haleon US Holdings
Dosage forms	Topical	Capsule, Tablet
Drug class	—	—
Boxed warning	None	None
Half-life	—	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)
Treats	Blister	—

abreva advil cold and sinus

Rating

72/100

Pharmacy pays

$6.64 /g

$0.04 /mL

Type

OTC

Active ingredient

DOCOSANOL

IBUPROFEN AND PSEUDOEPHEDRINE HYDROCHLORIDE

Manufacturer

Haleon US Holdings

Dosage forms

Topical

Capsule, Tablet

Drug class

—

Boxed warning

None

Half-life

—

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

Treats

Blister

—

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Frequently asked questions

Which is better-rated, Abreva or Advil Cold and Sinus?

Abreva and Advil Cold and Sinus are tied at 3.6 out of 5 by our independent rating.

What is the difference between Abreva and Advil Cold and Sinus?

Abreva contains Docosanol, while Advil Cold and Sinus contains Ibuprofen and Pseudoephedrine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.