Tumor Necrosis Factor Blocker drugs compared
Compare all 6 Tumor Necrosis Factor Blocker drugs side by side, used for conditions such as arthritis, juvenile, arthritis, rheumatoid, colitis, ulcerative. They share one FDA-defined mechanism but differ in approved uses, prescription status, brand-vs-generic options, price, and FDA recall-safety record — which our independent rating scores. The highest-rated is humira.
Top-rated tumor necrosis factor blocker: 1. Humira · 2. Cimzia · 3. Enbrel
| Drug | Generic | Form | Status | Used for | Safety ratingFDA recall-based | Pharmacy pays |
|---|---|---|---|---|---|---|
| Humira | Adalimumab | Kit | Prescription | Arthritis, Juvenile, Arthritis, Rheumatoid | 72/100 | — |
| Cimzia | Certolizumab Pegol | Injectable | Prescription | Arthritis, Rheumatoid, Crohn Disease | 70/100 | — |
| Enbrel | Etanercept | Solution | Prescription | Arthritis, Juvenile, Arthritis, Rheumatoid | Not yet rated | — |
| Inflectra | Infliximab-Dyyb | Injectable | Prescription | Arthritis, Rheumatoid, Colitis, Ulcerative | Not yet rated | — |
| Remicade | Infliximab | Injectable | Prescription | Arthritis, Rheumatoid, Colitis, Ulcerative | Not yet rated | — |
| Zymfentra | Infliximab-Dyyb | Injectable | Prescription | Arthritis, Rheumatoid, Colitis, Ulcerative | Not yet rated | — |
The safety rating column is unique to pharmaranks — an independent 0–100 score from FDA regulatory recall data. Higher is safer. Not medical advice.
Best tumor necrosis factor blocker by condition
Full ranking · 6 drugs
- 172/100
humira
Adalimumab
- 270/100
cimzia
Certolizumab Pegol
- 3New
enbrel
Etanercept
- 4New
inflectra
Infliximab-Dyyb
- 5New
remicade
Infliximab
- 6New
zymfentra
Infliximab-Dyyb
Frequently asked questions
What is the Tumor Necrosis Factor Blocker drug class?
Tumor Necrosis Factor Blocker is an FDA Established Pharmacologic Class (EPC) — a group of drugs that share a mechanism of action. pharmaranks lists 6 Tumor Necrosis Factor Blocker products, each independently rated.
Are all Tumor Necrosis Factor Blocker drugs the same?
No. Tumor Necrosis Factor Blocker drugs share the same core mechanism — that is why they sit in one FDA class — but they differ in their approved uses, available forms, whether they are prescription or over-the-counter, brand-vs-generic options and price, and their FDA recall-safety record.
What conditions do Tumor Necrosis Factor Blocker drugs treat?
Per NIH RxClass drug-classification data, Tumor Necrosis Factor Blocker drugs are used for conditions including arthritis, juvenile, arthritis, rheumatoid, colitis, ulcerative, crohn disease, spondylitis, ankylosing, uveitis.
Which Tumor Necrosis Factor Blocker drug is best-rated?
By our independent rating, humira currently ranks highest among Tumor Necrosis Factor Blocker drugs. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.
Sources: the Tumor Necrosis Factor Blocker class definition and its member drugs come from the U.S. NLM RxClass (Established Pharmacologic Class). Ratings are pharmaranks’ independent FDA recall-safety analysis.