Triptans compared
Compare all 11 triptans side by side, used for conditions such as cluster headache, migraine disorders. Triptans are the Serotonin-1b and Serotonin-1d Receptor Agonist class. They share one FDA-defined mechanism but differ in approved uses, prescription status, brand-vs-generic options, price, and FDA recall-safety record — which our independent rating scores. The highest-rated is imitrex.
Top-rated serotonin-1b and serotonin-1d receptor agonist: 1. Imitrex · 2. Maxalt · 3. Maxalt-Mlt
| Drug | Generic | Form | Status | Used for | Safety ratingFDA recall-based | Pharmacy pays |
|---|---|---|---|---|---|---|
| Imitrex | Sumatriptan | Injectable | Prescription | Cluster Headache, Migraine Disorders | 70/100 | $482 |
| Maxalt | Rizatriptan Benzoate | Tablet | Prescription | Migraine Disorders | 70/100 | — |
| Maxalt-Mlt | Rizatriptan Benzoate | Tablet | Prescription | Migraine Disorders | 70/100 | — |
| Zomig | Zolmitriptan | Spray/Inhaler | Prescription | Migraine Disorders | 70/100 | $67 |
| Eletriptan Hydrobromide | — | Tablet | Prescription | Migraine Disorders | 66/100 | — |
| Zolmitriptan | — | Spray/Inhaler | Prescription | Migraine Disorders | 66/100 | $67 |
| Onzetra Xsail | Sumatriptan Succinate | Capsule | Prescription | Cluster Headache, Migraine Disorders | Not yet rated | $482 |
| Relpax | Eletriptan Hydrobromide | Tablet | Prescription | Migraine Disorders | Not yet rated | — |
| Rizafilm | Rizatriptan Benzoate | Film | Prescription | Migraine Disorders | Not yet rated | — |
| Sumatriptan Succinate | — | Injectable | Prescription | Cluster Headache, Migraine Disorders | Not yet rated | $482 |
| Tosymra | Sumatriptan | Spray/Inhaler | Prescription | Cluster Headache, Migraine Disorders | Not yet rated | $482 |
The safety rating column is unique to pharmaranks — an independent 0–100 score from FDA regulatory recall data. Higher is safer. Not medical advice.
Best serotonin-1b and serotonin-1d receptor agonist by condition
Full ranking · 11 drugs
- 170/100
imitrex
Sumatriptan
- 270/100
maxalt
Rizatriptan Benzoate
- 370/100
maxalt-mlt
Rizatriptan Benzoate
- 470/100
zomig
Zolmitriptan
- 566/100
eletriptan hydrobromide
Eletriptan Hydrobromide
- 666/100
zolmitriptan
Zolmitriptan
- 7New
onzetra xsail
Sumatriptan Succinate
- 8New
relpax
Eletriptan Hydrobromide
- 9New
rizafilm
Rizatriptan Benzoate
- 10New
sumatriptan succinate
Sumatriptan Succinate
- 11New
tosymra
Sumatriptan
Frequently asked questions
What is the Serotonin-1b and Serotonin-1d Receptor Agonist drug class?
Serotonin-1b and Serotonin-1d Receptor Agonist is an FDA Established Pharmacologic Class (EPC) — a group of drugs that share a mechanism of action. pharmaranks lists 11 Serotonin-1b and Serotonin-1d Receptor Agonist products, each independently rated.
Are all Serotonin-1b and Serotonin-1d Receptor Agonist drugs the same?
No. Serotonin-1b and Serotonin-1d Receptor Agonist drugs share the same core mechanism — that is why they sit in one FDA class — but they differ in their approved uses, available forms, whether they are prescription or over-the-counter, brand-vs-generic options and price, and their FDA recall-safety record.
Is "triptans" the same as the Serotonin-1b and Serotonin-1d Receptor Agonist class?
Yes — "triptans" is the everyday name for the Serotonin-1b and Serotonin-1d Receptor Agonist drug class. This page compares the 11 triptans pharmaranks rates, with our independent FDA recall-safety score for each.
What conditions do Serotonin-1b and Serotonin-1d Receptor Agonist drugs treat?
Per NIH RxClass drug-classification data, Serotonin-1b and Serotonin-1d Receptor Agonist drugs are used for conditions including cluster headache, migraine disorders.
Which Serotonin-1b and Serotonin-1d Receptor Agonist drug is best-rated?
By our independent rating, imitrex currently ranks highest among Serotonin-1b and Serotonin-1d Receptor Agonist drugs. Ratings are based on FDA regulatory (recall-safety) data — always consult a professional.
Sources: the Serotonin-1b and Serotonin-1d Receptor Agonist class definition and its member drugs come from the U.S. NLM RxClass (Established Pharmacologic Class); how the class works is summarized from Triptans - StatPearls - NCBI Bookshelf. Ratings are pharmaranks’ independent FDA recall-safety analysis.